In an experimental
study in rats, streptozotocin given intraperitoneally in a dose
of 45 mg/kg body weight of animals, effectively produced
hyperglycaemia (Punithavathi et al.; Fadillioglu et al.). In
another study in rats, STZ injected in a dose of 65 mg/kg
body weight effectively produced hyperglycemia and gastric
mucosal ulcerations (Piyachaturawat et al., 1988; 1990).