The difference in crystal faces affects the nature of each
crystal habit which influences the dissolution of a drug [5].
Adhiyaman and Basu [6] reported that the dissolution
enhancement of dipyridamole correlates to alteration of the
drug habit by crystallization using different solvents, additives
and crystallization conditions. The dissolution rate of
rod-shaped particles crystallized from benzene is notably
more rapid than that of rectangular needle-shaped crystals
produced using methanol. The effect of crystal habit on
tolbutamide dissolution was also suggested [7]. The smallest
particle size, plate-like shape crystals adopted from solventchange
method using methanol and ethanol show higher
dissolution rate.