Methionine is encoded by a single codon (AUG) in
the standard genetic code. The codon AUG is also the
“start” message for a ribosome that signals the initiation
of protein translation from mRNA. As a consequence,
Met is incorporated into the N-terminal position
of all proteins in eukaryotes and archaea during
translation (Berg et al., 2002). In the current study,
dietary treatments imposed to these broiler chickens
resulted in markedly different pectoral muscle development,
thus allowing for a valid proteome comparison to
obtain a better understanding of dietary Met-induced
metabolic and physiological differences. Protein expression
was affected by Met supplementation, as indicated
by higher absolute and relative muscle weights, as
well as changes in 6 canonical pathways. However, 2
pathways (Germ cell-sertoli cell junction signaling and
cellular effects of sildenafil) are important only in the
male reproductive system. Their functions in muscle
development remain obscure and should require further
Methionine is encoded by a single codon (AUG) inthe standard genetic code. The codon AUG is also the“start” message for a ribosome that signals the initiationof protein translation from mRNA. As a consequence,Met is incorporated into the N-terminal positionof all proteins in eukaryotes and archaea duringtranslation (Berg et al., 2002). In the current study,dietary treatments imposed to these broiler chickensresulted in markedly different pectoral muscle development,thus allowing for a valid proteome comparison toobtain a better understanding of dietary Met-inducedmetabolic and physiological differences. Protein expressionwas affected by Met supplementation, as indicatedby higher absolute and relative muscle weights, aswell as changes in 6 canonical pathways. However, 2pathways (Germ cell-sertoli cell junction signaling andcellular effects of sildenafil) are important only in themale reproductive system. Their functions in muscledevelopment remain obscure and should require further
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