With continuing evidence of S. marcescens healthcare-associated infection it is apparent that opportunities for infection control not only depend on the prudent use of antimicrobials but also on the implementation of effective infection control policies (54). If an increase in the incidence of S. marcescens infections is evident, the infection-control team should become involved to prevent spread within the hospital, particularly when multi-resistant strains are isolated (57). As in all aspects of infection control hand hygiene is the most important component, and when S. marcescens is encountered, this should be re-emphasized to all healthcare personnel. Cohorting patients in specified rooms or units to minimise contact between personnel and non-infected patients with consideration of isolation measures may also be indicated.