3.3. Electron microscope
The presence of viral particles in nodules of affected skin was
observed by transmission electron micrographs. These dispersed
particles were in the cytoplasm of hypertrophied cells. Large
icosahedral viral particles, 200 nm in diameter, revealed an electron
dense nucleocapsid and well-defined electron-lucent envelopes with
surface-associated fibrils (Fig. 1E and F).