Serial Cardiac Troponin Levels
The AUC for all cardiac troponin assays increased
further at the later sampling points (Table 3B
in the Supplementary Appendix). For example,
3 hours after presentation, the AUC for the sensitive
and the standard cardiac troponin assays
was 0.98.
The diagnostic performance of the absolute
value of changes in cardiac troponin levels from
presentation to 1 hour and to 2 hours was similar
to the performance of cardiac troponin levels
at presentation (Table 3C in the Supplementary
Appendix). The combination of the baseline level
and early changes resulted in a nonsignificant
further improvement in diagnostic performance
as compared with the baseline level alone.