In conclusion, the histological observation and liver injury marker
gene expression data demonstrated that EVOO is more beneficial than
corn oil to provide hepatoprotective effects against CCl4-induced liver
fibrosis. This better protection may be attributed to the ω-9 MUFA oleic
acid and anti-oxidative polyphenols in EVOO (de la Torre, 2008). In the
scope of our knowledge, this proteomics studywas the first global view
of hepatic protein expression modification in CCl4 induced liver fibrosis
animals fed with high EVOO or corn oil, allowing us to develop a
better understanding of the molecular mechanisms of the different
effects of dietary lipids against chronic liver injury