This chapter has discussed the multitude of data and information in contemporary global supply chains and how they can be managed and used. Through the synthesis and analysis of data, we gain information. For example, from the interaction between an RFID reader and RFID tags, time and location data can be acquired. By transmitting this to a middleware for synthesis and analysis, information about the movement of freight and delivery lead time can be generated and transmitted to a central management information system to be interrogated by other software applications such as ERP and accessed by users. Using this information and synthesizing it with other business information can create knowledge. That is to say, through internalization and understanding of information, knowledge is gained. Hence global supply chains are also filled with knowledge, some of which is tacit and some of which is made explicit via knowledge repositories and information system. Knowledge management is the term used to describe the capture, storage, use and sharing of knowledge within an organization. The term “supply chain knowledge management” is therefore introduced here to describe those knowledge management processes that span a supply chains.