confirmation of the effect in vivo was tested by orally exposing B6C3F1 mice to t.indica extact for 14 days and evaluating NO production by freshly isolated peritoneal maccroplages following stimulation in vitro with lipopolysaccharide (lps) and/or interferon gamma (IFN-?) and in vivo or in vitro with 12-tetradecanoylphorbol- 13-acetate (TPA).