During the period of assessments of the disease in 2004–2006, CWD was detected in all the indigenous coffee field sites. The lowest percentage of infected trees was found in Berhane-Kontir, the highest in Yayu (Table 4). Seedling inoculation results showed that there existed significant differences among the tested accessions, and most of the coffee accessions collected from Harenna appeared to be highly resistant to CWD with infection rates between 0% and 4.0%. Some of the Bonga accessions had infection rates of 60–97%, Berhane-Kontir of 78–98% and Yayu of 56–98%. Seedlings of coffee accessions possessing moderate to high resistance to the CWD pathogen were grown, re-inoculated with the same fungus isolate and transferred to greenhouse and field sites for further observation.