Level 0 (normal): normal liver morphology, hepatocytes had
the round nucleus centrally and homogenous cytoplasm, the
flat endothelial cells around central vein and sinusoid.
• Level +1 (mild degree): some of 1–2 hepatocyte rows around
central vein demonstrated hepatic cell degeneration, necrosis
(loss of nucleus), less injury of endothelial cells around central
vein and less fat vacuoles in hepatocytes.
• Level +2 (moderate degree): hepatocyte rows around central
vein had swelling, intracytoplasmic vacuolar degeneration in
centrilobular, midzonal and periportal areas, endothelial cells
around central vein more injury than level +1 and increasing
of fat vacuoles in hepatocytes as compared with level +1.
• Level +3 (severe degree): three to four hepatocyte rows around
central vein showed hepatocytic degeneration and necrosis
(loss of nucleus), degeneration cells including centrilobular, midzonal and periportal areas (diffuse intracytoplasmic
vacuolar degeneration), endothelial lining of central vein
exhibited more cell injury, as well as increasing of fat vacuoles in hepatocytes as compared with level +2. Besides, focal
necrosis and bile duct proliferation were marked.
2.8. Statistical analysis
The data were expressed as mean±S.E.M. Results were analyzed statistically by one-way analysis of variance (ANOVA)
followed by Tukey’s test using the SPSS 11.5 for Window software. P-value
Level 0 (normal): normal liver morphology, hepatocytes had
the round nucleus centrally and homogenous cytoplasm, the
flat endothelial cells around central vein and sinusoid.
• Level +1 (mild degree): some of 1–2 hepatocyte rows around
central vein demonstrated hepatic cell degeneration, necrosis
(loss of nucleus), less injury of endothelial cells around central
vein and less fat vacuoles in hepatocytes.
• Level +2 (moderate degree): hepatocyte rows around central
vein had swelling, intracytoplasmic vacuolar degeneration in
centrilobular, midzonal and periportal areas, endothelial cells
around central vein more injury than level +1 and increasing
of fat vacuoles in hepatocytes as compared with level +1.
• Level +3 (severe degree): three to four hepatocyte rows around
central vein showed hepatocytic degeneration and necrosis
(loss of nucleus), degeneration cells including centrilobular, midzonal and periportal areas (diffuse intracytoplasmic
vacuolar degeneration), endothelial lining of central vein
exhibited more cell injury, as well as increasing of fat vacuoles in hepatocytes as compared with level +2. Besides, focal
necrosis and bile duct proliferation were marked.
2.8. Statistical analysis
The data were expressed as mean±S.E.M. Results were analyzed statistically by one-way analysis of variance (ANOVA)
followed by Tukey’s test using the SPSS 11.5 for Window software. P-value <0.05 was regarded as statistically significant.
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