Hydrochlorothiazide: Hydrochlorothiazide is not metabolized but is eliminated rapidly by the
kidney. The plasma half-life is 5.6-14.8 hours when the plasma levels can be followed for at least
24 hours. At least 61% of the oral dose is eliminated unchanged within 24 hours.
Hydrochlorothiazide crosses the placental but not the blood-brain barrier and is excreted in
breast milk.