Mycoplasma synoviae can cause respiratory disease, infectious synovitis and eggshell apex
abnormality in chickens and turkeys, thus the bacterium has economic importance in poultry
industry. M. synoviae infection may occur from sub-clinical to severe forms, and the clinical
signs change markedly when Mycoplasma infection is associated with other pathogens [1–3].
M. synoviae has a worldwide distribution and its occurrence is increasing. Less attention paid
to control programs, biosecurity lapses at farms and large concentration of poultry in small
geographic areas could accelerate the spread of M. synoviae infection [4]. M. synoviae may be
transmitted either vertically through the eggs, or laterally by direct contact or indirect contact
via the environment [1,5]. There are three general aspects in the control of M. synoviae infection:
eradication and maintaining pathogen-free status by prevention, medication or vaccination