Chronic exposure to cadmium leads to damage to several organs and systems primarily the kidney. Our results showed a significant increase in cadmium level in blood and urine as has been reported elsewhere. cadmium exposure increased body, kidneys and liver weight. The high concentrations of cadmium in blood and urine indicated a high level exposure. This high exposure and organ weight increase indicated cadmium toxicity could have resulted from cadmium-associated pathologies in renal tubular epithelium such as calcuria, magnesuria and proteinuria as well as bone demineralization and anemia. In this study, we observed the degenerative changes in rat kidney and liver accorded with the high blood cadmium concentrations.