Two months later, the patient was admitted to the neurology department of our hospital because of bilateral numbness of the lower legs, unsteady gait, difficulty in defecation, and urine retention for the past week. In addition, worsened migraine was noted again. Neurological examination showed bilateral pinprick-sensation and vibration impairment over the L1–L2 dermatome, positive Romberg test results, poor coordination, and short steps with wide-based gait. The follow-up brain MRI revealed that the above-mentioned lesions had increased in number and size, as observed on T2-weighted images. After gadolinium contrast injection, more prominent ring and incomplete ring enhancements over these lesions, including those in the PAG, were noted on T1-weighted images. In the sagittal view, MS plaques with an increased number of Dawson’s fingers were noted (Figure 2). These signs were suggestive of disease progression with active demyelination. On the basis of our physical observation, we performed a low thoracic and lumbar spine MRI, which showed a hyperintense lesion in the spinal cord (T9 level) on T2-weighted images and enhancement after gadolinium injection (Figure 3).