The in vivo anti-inflammatory activities of CHCl3 fraction from Boesenbergia longiflora and the standard drug indomethacin against carrageenan-induced paw edema. The injection of carragenan caused localized edema starting at 0.5 h and progressively increased swelling to a maximum volume at 5 h after injection. The peak activity was observed at 2 h after induction. The CHCl3 fraction significantly reduced paw volume at 2 h, however, the inhibition of rat paw edema offered by CHCl3 fraction was relatively lower than that of the positive control, indomethacin, at 10 mg/kg dose (69.3% inhibition at 2 h after induction). The anti-inflammatory effects of the CHCl3 fraction and indomethacin were slightly decreased after 3 h but their effects still retained till the end of study period (5 h).