Skin is the second largest organ in the body after the skeleton and it consists of three structural layers including epidermis, dermis and subcutis. Epidermis is a terminally differentiated, stratified squamous epithelium composed of predominantly keratinocytes. Dermis is a complex tissue comprising many different cell types. Subcutis is the fatty tissue below the skin and consists of spongy connective tissue distributed with the energy-storing fat cells (McElwee & Sinclair, 2008). Within these generalized layers of the skin are specialized derivatives structures of skin including hair, nails, sensory nerves, arrector pili muscle, blood supply, sebaceous, sweat and apocrine glands (Figure 1) (Ro and Dawson, 2005).