The ionotropic gelation technique, as the most important technique for ionic cross-linking
of chitosan with low molecular weight counterions, hydrophobic counterions and high molecular
weight ions, involve sodium tripolyphosphate (TPP), too [7-10]. Chitosan microspheres as a
potential carrier for drugs [11, 12], like anticancer agents and vaccines [13-16] are the most widely studied systems
The ionotropic gelation technique, as the most important technique for ionic cross-linkingof chitosan with low molecular weight counterions, hydrophobic counterions and high molecularweight ions, involve sodium tripolyphosphate (TPP), too [7-10]. Chitosan microspheres as apotential carrier for drugs [11, 12], like anticancer agents and vaccines [13-16] are the most widely studied systems
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