Chronic obstructive pulmonary disease (COPD) is a multicomponent disease characterized by a progressive and irreversible decline in lung function caused by airflow obstruction, destruction of parenchyma and emphysema, patients with COPD always manifested by the symptoms of emphysema and chronic bronchitis (shortness of breath, increasing cough and sputum production) [1]. COPD was responsible for 5% of deaths globally in 2005 and it is projected to be the fourth leading cause of death by 2030