In conclusion, our investigation indicated that sorghum, the fifth most important cereal in the world, is an effective inhibitor of glucosidase, with inhibitory activity against stearothermophilus a-glucosidase as well as porcine pancreatic and human salivary a-amylases. Although the inhibitory effect of sorghum extracts has been established in vitro, these findings indicate that sorghum extract may potentially suppress the increase in post-prandial glucose by starch. Further studies should be the isolation and characterisation of the active compounds from sorghum extracts using various techniques.