adenosine triphosphate (ATP)-sensitive K+ channels, which
causes hyperpolarization of the β-cell membrane, with a reduced
rate of opening of voltage-dependent Ca2+ channels
and the eventual elimination of Ca2+ influx (11, 12). Adverse
reactions in the form of fluid retention and edema have also
been reported, highlighting the need for strict caution in patients
with a decreased cardiac or renal function (13). For
this reason, we exercised caution when increasing the current
patient’s dose of treatment. Consequently, CGM
showed that the serious hypoglycemic attacks resolved with
the oral administration of diazoxide at a dose of 250 mg/
day. Gill et al. (13) reported that symptoms improved and/or
resolved in 59% of 40 insulinoma patients who received diazoxide
over a period of approximately seven years. In Japan,