In addition to medication, all patients
received a form of manualized
cognitive behavioral therapy found to
be useful in reducing relapse in anorexia
nervosa.9 Experienced psychologists
and psychiatrists provided therapy,
which consisted of 50 individual sessions
of 45 minutes’ duration. Patients
were able to have up to 5 supplemental
sessions with family members
and/or significant others. A psychiatrist
saw patients to monitor the dose
of medication, adverse effects, and general
medical status. Therapy sessions
were audiotaped and reviewed by 2 of
the authors (K.M.P. and M.J.D.) to assess
treatment fidelity and adherence.
Blood samples were obtained every 3
months for determination of plasma levels
of fluoxetine and nor-fluoxetine.