Glial fibrillary acidic protein (GFAP) is a protein that is encoded by the GFAP gene in humans.[1]
Glial fibrillary acidic protein is an intermediate filament (IF) protein that is expressed by numerous cell types of the central nervous system (CNS) including astrocytes,[2] and ependymal cells.[3] GFAP has also been found to be expressed in glomeruli and peritubular fibroblasts taken from rat kidneys[4] Leydig cells of the testis in both hamsters[5] and humans,[6] human keratinocytes,[7] human osteocytes and chondrocytes[8] and stellate cells of the pancreas and liver in rats.[9] First described in 1971,[10] GFAP is a type III IF protein that maps, in humans, to 17q21.[11] It is closely related to its non-epithelial family members, vimentin, desmin, and peripherin, which are all involved in the structure and function of the cell’s cytoskeleton. GFAP is thought to help to maintain astrocyte mechanical strength,[12] as well as the shape of cells but its exact function remains poorly understood, despite the number of studies using it as a cell marker. Glial fibrillary acidic protein (GFAP) was named and first isolated and characterized by Lawrence F. Eng in 1969
Glial fibrillary acidic protein (GFAP) is a protein that is encoded by the GFAP gene in humans.[1]Glial fibrillary acidic protein is an intermediate filament (IF) protein that is expressed by numerous cell types of the central nervous system (CNS) including astrocytes,[2] and ependymal cells.[3] GFAP has also been found to be expressed in glomeruli and peritubular fibroblasts taken from rat kidneys[4] Leydig cells of the testis in both hamsters[5] and humans,[6] human keratinocytes,[7] human osteocytes and chondrocytes[8] and stellate cells of the pancreas and liver in rats.[9] First described in 1971,[10] GFAP is a type III IF protein that maps, in humans, to 17q21.[11] It is closely related to its non-epithelial family members, vimentin, desmin, and peripherin, which are all involved in the structure and function of the cell’s cytoskeleton. GFAP is thought to help to maintain astrocyte mechanical strength,[12] as well as the shape of cells but its exact function remains poorly understood, despite the number of studies using it as a cell marker. Glial fibrillary acidic protein (GFAP) was named and first isolated and characterized by Lawrence F. Eng in 1969
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