Many different radioactive isotopes and techniques are used for dating. All rely on the fact that certain elements (particularly uranium and potassium) contain a number of different isotopes whose half-life is exactly known and therefore the relative concentrations of these isotopes within a rock or mineral can measure the age. For an element to be useful for geochronology (measuring geological time), the isotope must be reasonably abundant and produce daughter isotopes at a good rate.
Either a whole rock or a single mineral grain can be dated. Some techniques place the sample in a nuclear reactor first to excite the isotopes present, then measure these isotopes using a mass spectrometer (such as in the argon-argon scheme). Others place mineral grains under a special microscope, firing a laser beam at the grains which ionises the mineral and releases the isotopes. The isotopes are then measured within the same machine by an attached mass spectrometer (an example of this is SIMS analysis).