Poly(ε-caprolactone) (PCL) electrospun nanofibers have been reported as a scaffold for tissue engineering
application. However, high hydrophobicity of PCL limits use of functional scaffold. In this study, PCL/
polyethylenimine (PEI) blend electrospun nanofibers were prepared to overcome the limitation of PCL ones
because the PEI as a cationic polymer can increase cell adhesion and can improve the electrospinnability of
PCL. The structure, mechanical properties and biological activity of the PCL/PEI electrospun nanofibers were
studied. The diameters of the PCL/PEI nanofibers ranged from 150.4±33 to 220.4±32 nm. The PCL/PEI
nanofibers showed suitable mechanical properties with adequate porosity and increased hydrophilic
behavior. The cell adhesion and cell proliferation of PCL nanofibers were increased by blending with PEI due
to the hydrophilic properties of PEI.