The aim of this work w as develop a b-lap deliverysystem using AL-CS hydrogel beads assayed in vitrowith simulated gastric fluid (SGF) for purposes oforal administration. The influence of the b-lap load-ing conditions on hydrogel beads in the releasekinetics studies were carried out. The hydrogelbeads were characterized with regard to their mor-phology, swelling ratio, and their physicochemicalproperties. FTIR, DSC, and X-ray analysis reveal thepresence of interation between AL and CS, but DSCand X-ray studies did not show any significant drug interactio n with the biopolymers used. Effectiverelease of b-lap occurred in simulated colonic fluid(SCF) with retanined release in simulated gastricfluid (SGF). This retention of the drug in acid me-dium, occured especially in the early hours, whilethere was a more pronounced release of the drug inalkaline medium, which simulates the phase of drugabsorption. Therefore, the beads are stable in acidmedium, important criterion to oral delivery of bio-active compound s.