Pharmacology
Experimental pharmacology
Effects on streptozotocin-induced diabetes
The effects of a dried ethanol extract of the fruit pulp (1 kg fruit pulp minus
seeds in 1500 ml 95% ethanol) were investigated in a normal glucoseprimed
rat model and streptozotocin-induced diabetic rats. Oral administration
of the extract, at a dose of 500.0 mg/kg body weight (bw), reduced
the plasma glucose levels in normal rats by 10–15% after 1 hour. In rats
with streptozotocin-induced diabetes, the extract significantly improved
the oral glucose tolerance (p < 0.002) and reduced plasma glucose by 26%
at 3.5 hours while metformin caused a 40–50% reduction after 1, 2 and
3.5 hours