One must recognize that the long-term clinical benefits of the alterations in the endothelial function detected in the present study are not known, consequently, it would be quite interesting to verify if these results are maintained in a longer follow-up period. On the other hand, the benefits of dark chocolate in other clinical sets where cardiovascular risks is manifest are also to be demonstrated; however, a the observation of a positive modulator effect can be anticipated Furthermore, there is the need of clinical trials with other sources of flavonoids besides chocolate, in a larger scale, in more diversified clinical contexts and with longer follow up periods