Proteolysis is caused by proteolytic enzymes
Exo-protease cleaves peptide bonds at the end of polypeptide chain
Endo-protease cleaves internal peptide bonds
Classification of proteases based on the group at their active sites
Serine protease I (mammalian) and II (bacterial);
Metalloproteases I (mammalian) and II (bacterial);
Cysteine proteases;
Aspartic proteases.
Acid and base hydrolysis degrade
-X-Asp-Y rapidly, even a low conc