Each patient received an intravenous (IV) infusion of
zoledronic acid 4 mg over 15 min every month for 6 doses.
Delays of administration were required for notable changes
in serum creatinine (SCr) level [Table 1]. For patients with a
notable increase in SCr, the next dose was withheld until the
SCr level returned to within 10% of the baseline SCr level.