The multifarious manifestations of CRF include feelings of exhaustion and lack of energy, loss of drive and personal interests, and impaired memory and concentration. The affected patients vary widely in their manner of expressing and describing the problems that they experience. Qualitative studies have shown that the clinical features are highly individual, and hardly any two patients are alike (5, e1). Typically, no clear relation exists between the symptoms and whatever activities immediately precede them; moreover, unlike normal fatigue and exhaustion, CRF often fails to improve, or does so only slightly, after rest or sleep (6). Many patients also suffer from pain, sleep disturbances, and emotional distress, including anxiety and depression (