Scutellaria agrestis is a prostrateplant, with straight branches reaching approximately 450 mm in height, branched; pubescente, with hairs throughout the aerial part of the plant. The stem is square, and purplish in color (Figure 1A).The phyllotaxy follows an opposite and crossing pattern (Figure 1B). The petiole measures around 6-10 mm in length and is purple in color. The leaf blade is simple and bicolor, with a green adaxial side and a purple abaxial side; it presents prominent primary and secondary vein formation (Figure 1B) and membranaceous texture. The leaf blade is oval to cordiform; the apex is sharpened and slightly retuse at the end when observed in stereoscope; the base is cordate, with a convexly indented and slightly crenate margin (Figures 1B; 2A-D). The flowers are labiate, ranging from white to violent, arranged in a terminal inflorescence, forming a type of crest (Figures 1A, 1C). The pattern of vein formation of the leaf blade of S. agrestis is of the eucamptodrome and basal acrodome types, with randomized areolation, i.e. without any preferential orientation pattern, whether in the format of the areolae or in the venule terminations (Figures 2A-D). Several tector trichomes with preserved cytoplasmatic content and different sizes are distributed throughout the leaf surface, and may be comprised of single or multiple cells (2-7 cells) and uniseriate; they are generally slightly curved at the apex and rarely straight, and are coated with a granulous cuticle (Figures 3A-D). Long tector trichomes with a higher number of cells are observed on the adaxial side, covering the entire surface of the leaf blade, while small trichomes are concentrated at the margins, covering the veins on both sides (Figures 3A-B). Capitate and peltate multiple cell glandular trichomes are observed on both sides of the leaf blade, with a larger number of peltated trichomes on the abaxial side (Figure 3 D-E). The capitate trichome has a short pedicel and approximately four cells composing the head (Figures 3E-F). Meanwhile, the peltate trichomes are usually located in a slight depression, with a short pedicel and multiple cell head composed of 5-12 cells, and a cuticle that distends with the accumulation of synthesized compound in the subcuticular space (Figures 3E, 3G). The leaf is amphi-hypostomatic, with diacytic stomata (Figures 3H-I), and is slightly higher than theother epidermal cells (Figure 3J). In frontal view, the leaf blade has an epidermis with a sinuous anticlinal wall and convex to conical periclinal wall, on both sides (Figures 3H-I). The epidermis is uniseriate, with a smooth external periclinal wall, which is thicker than the inner wall, covered by a thin, lipidic cuticle (Figures 3J, 3K). The epidermal cells are