Hotel Safe Considerations
Depending on the type and age of your hotel, typically safes which let you select your own combination are safer than room safes with keys that may have had keys copied by dishonest hotel employees.
Some travelers report that their credit card numbers may have been compromised by someone who may have entered their hotel safe and copied down their numbers. This is very hard to prove. Some travelers place their credit cards in a sealed envelope in their hotel room safe so they can tell if this has occurred.
Research your hotel online - TripAdvisor.com is a great research site - look for terms such as theft from hotel room safes or related comments. Here is a link to give you an idea of some travelers comments on the theft of items from their hotel safes overseas. Unfortunately in some hotels, dishonest employees use master keys to remove items from your hotel safe when you are away. This tens to be a larger problem outside the United States.
If you want a higher level of security for your room safe, consider purchasing your own personal hotel safe lock that lets you place your own lock on your safe. Only one hotel safe lock is on the market today to allow you to better safeguard your safe's valuables. This product, the Milockie Hotel Safe Lock can be reviewed here.