TGA is used as a chemical depilatory and is still used as such, especially in salt forms, including calcium thioglycolate and sodium thioglycolate. TGA is the precursor to ammonium thioglycolate that is used for permanents. TGA and its derivatives break the disulfide bonds in the cortex of hair. One reforms these broken bonds in giving hair a "perm." Alternatively and more commonly, the process leads to depilation as is done commonly in leather processing. It is also used as an acidity indicator, manufacturing of thioglycolates, and in bacteriology for preparation of thioglycolate media.[5] In fact thioglycolysis reactions used on condensed tannins to study their structure.
Organotin derivatives of thioglycolic acid isooctyl esters are widely used as stabilzers for PVC. These species have the formula R2Sn(SCH2CO2C8H17)2.[5]
Applying TGA can soften nails and then fix pincer nails in the correct position.
Sodium thioglycolate is a component of a special bacterial growth media : thioglycolate broth.