Since the mid-1960s, there have been published
diagnostic criteria developed by MS experts that have
helped with the diagnosis of MS. In 2001, an international
panel of MS experts convened and developed
criteria that utilized both clinical and MRI findings,
including the criteria of dissemination in space and
time (McDonald et al., 2001). Since 2001, these criteria,
known as the McDonald criteria, have been
revised, both in 2005 (Polman et al., 2005) and in 2010
(Polman et al., 2011). In each of the revisions, the
MRI criteria have been modified to reflect increased
evidence of MRI changes consistent with MS.