Schizophrenia occurs in
approximately 0.3 to 0.7 percent of
the world’s population and is
associated with significant morbidity
and mortality. Although atypical
antipsychotics reduce positive and
negative symptoms, they are
associated with varying degrees of
metabolic adverse effects. This
necessitates continued development
of efficacious yet metabolically
favorable treatments. This article
reviews brexpiprazole, a medication
recently approved to treat patients
with schizophrenia. Brexpiprazole
was well-tolerated, and adverse
reactions were statistically
insignificant. They included nausea;
insomnia; headache; agitation;
akathisia; and weight gain or changes
in lipid, creatine phosphokinase,
glucose, or prolactin levels.
Brexpiprazole is taken once daily
without regard to food, and the dose
should be adjusted in patients who
receive moderate or strong CYP450
inhibitors or inducers and in patients
with hepatic or renal diseas