The largest study to address this issue (n51514) reported a 95% confidence interval for the
learning effect of 24–29 m [9]. There is some variability across individuals: the proportion of participants
who walked further on the second 6MWT ranged from 50% to 87% across studies. Fewer data are available
in other chronic respiratory diseases, although the available studies tend to support a learning effect across
all chronic respiratory diseases [1]. Whether the learning effect is equally significant for individuals who
have previously performed multiple 6MWTs is difficult to establish, as few data are available. If the tests are
repeated 3 months later, the learning effect appears to persist in individuals with COPD; however, it may be
smaller in magnitude