acetaminophen treatment groups (1,000 mg q6h and
650 mg q4h) produced statistically better satisfaction
ratings for the Subject Global Evaluation scale compared
with the control group. While satisfaction ratings are often
difficult to interpret in the absence of other efficacy
outcome measures, these positive results could be interpreted
as providing at least indirect evidence of an IV
acetaminophen treatment effect and additional confirmation
of its tolerability. The results are supported by more
than 40 randomized, controlled trials demonstrating effi-
cacy in a variety of acute pain (operative and nonoperative)
settings [18,19].
The results of this study are consistent with IV acetaminophen’s
long clinical record of safety and tolerability. With
rapid and effective analgesic activity and a favorable safety
profile, IV acetaminophen is poised to be a first-line analgesic
for the management and treatment of inpatient adult
pain and fever when IV treatment is clinically indicated or
when a fast onset of efficacy is desired.