The present study showed that brain activation corresponded to the applied N-back conditions, regardless of the treatment session. Specifically, the 2-back condition resulted in global brain activation, including the frontal lobe, occipital lobe, parietal lobe, temporal lobe, and subcortical area, whereas the 0-back condition activated limited brain regions, such as the frontal and occipital lobes. Additionally, the resultant cluster sizes were generally observed to be larger under the 2-back condition and smallest under the 0-back condition, implying that an increased load of executive control was positively correlated with extensive activated brain regions and with larger cluster sizes. The finding that brain activation reflected the demand for executive control is in agreement with previous studies [33], [34] and thus confirms the validity of the applied executive function task and functional MRI modality.
The present study showed that brain activation corresponded to the applied N-back conditions, regardless of the treatment session. Specifically, the 2-back condition resulted in global brain activation, including the frontal lobe, occipital lobe, parietal lobe, temporal lobe, and subcortical area, whereas the 0-back condition activated limited brain regions, such as the frontal and occipital lobes. Additionally, the resultant cluster sizes were generally observed to be larger under the 2-back condition and smallest under the 0-back condition, implying that an increased load of executive control was positively correlated with extensive activated brain regions and with larger cluster sizes. The finding that brain activation reflected the demand for executive control is in agreement with previous studies [33], [34] and thus confirms the validity of the applied executive function task and functional MRI modality.
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