Knapp said that hypertensive patients with progressive
kidney deterioration might be a consequence of little or no
fall in sleeping BP. He urged clinicians and clinical trialists to
be more thoughtful about the time of administration of
drugs in relation to biological rhythms, including the
circadian cycle (Martin 2004). BP exhibits strong circadian
variation, this may contribute to the increase of acute
cardiovascular events that peak in the morning hours.
Reducing morning BP may prevent these occurrences (Weber
& Fodera 2004).