Antiviral activity
The anti-influenza A (H2N2) virus activity of patchouli alcohol was studied in vitro, in vivo and in silico. The CC (50) of patchouli alcohol was above 20 µM. It could inhibit influenza virus with an IC (50) of 4.03 ± 0.23 µM. In the influenza mouse model, patchouli alcohol showed obvious protection against the viral infection at a dose of 5 mg-1kg-1day.56 The methanol extract from the leaves of P.cablin, showed potent in vitro antiviral activity (99.8% inhibition at a concentration of 10 µgmL-1) against influenza virus A/PR/8/34 (H1N1). Patchouli alcohol did not show anti-influenza virus activity against A/Guizhou/54/89 (H3N2)