In summary, multiple reports using various methods of analysis
identify a temporal association between PRBC transfusion
and the development of NEC in moderately anemic
VLBW neonates, a phenomenon that is referred to as TRAGI.
We believe that these retrospective reports are primarily useful
for hypothesis-generating purposes, as there is no definitive
proof for any of the mechanisms we reviewed. There
appears to be a need for a call to action using a randomized
clinical trial of sufficiently large sample size to decisively link