Mono, like many viral illnesses, just needs to run its course and it usually resolves without treatment. Antiviral drugs are not effective for treating mono. There's some evidence these medications prolong mono infection. Treatment for mono is supportive and focuses on symptom relief. Aches, pains, fever, and headache can be treated with acetaminophen. Plenty of rest, sleep, and fluids can help ease symptoms. Painful, sore throat -- one of the most uncomfortable symptoms of mono -- is typically the worst during the first 5 to 7 days of the infection. Sore throat resolves and gets much better in the subsequent 7 to 10 days