Increased Effect Toxcity: Disulfiram and probenecid may increase amoxicilli levels. Amoxicillin may increase the effects of oral anticoagulants (warfarin). Theoretically, allopurinol taken with amoxicillin has an additive potential amoxicillin rash. Penicillins r increase the exposure to methotrexate during concurrent therapy, monitor
Decreased Effect: Decreased effectiveness with tetracyclines and chloramphen Although anecdotal reports suggest oral contraceptive efficacy could be reduced by penicillins, this has been refuted by more rigorous scientific and clinical data
Stability Amoxile: Oral suspension remains stable for 14 days at room temperature or if refrigerated (refrigeration preferred), unit-dose antibiotic oral syringes are stable for 48 hours DisperMox M: Dissolve 1 tablet in 10 mL water immediately before use
Mechanisin of Action Inhibits bacterial cell wall synthesis by billding to one or more of t penicillin-binding proteins (PBPs); which in turn inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls, thus inhibiting cell wall biosynthesis. Ba eventually lyse due to ongoing activity of cell wall autolytic enzymes (autolysins and mureir hydrolases) while cell wall assembly is arrested