This study mainly integrates the mature Technology-Organization-Environment(TOE) framework and recently developed Human-Organization-Technology (HOT) fit modelto identify factors that affect the hospital decision in adopting Hospital Information System(HIS).Methods: Accordingly, a hybrid Multi-Criteria-Decision-Making (MCDM) model is used toaddress the dependence relationships of factors with the aid of Analytic Network Processes(ANP) and Decision Making Trial and Evaluation Laboratory (DEMATEL) approaches. The ini-tial model of the study is designed by considering four main dimensions with 13 variables asorganizational innovation adoption factors with respect to HIS. By using DEMATEL, the inter-dependencies strength among the dimensions and variables are tested. The ANP method isthen adopted in order to determine the relative importance of the adoption factors, and isused to identify how these factors are weighted and prioritized by the public hospital pro-fessionals, who are wholly familiar with the HIS and have years of experience in decisionmaking in hospitals’ Information System (IS) department.