proniosomes of curcumin were prepared by encapsulation of the drug in a mixture of Span 80, Cholesterol and diethyl ether by ether injection method, and then investigated as a transdermal drug delivery system (TDDS). The formulated systems were characterized for size, drug entrapment, angle of repose, hydration rate and vesicular stability under various storage conditions. In vitro release studies were perfomed using albino rat skin.