It is generally believed that the microbial behavior (growth andmetabolic profile) in SSF and SmF differ at times. When Li et al.[15] compared the cellulase production by Neurospora sitophila inSSF and SmF using steam exploded wheat straw as carbon source,highly interesting results were obtained. Not only the CMCase, FPAand -glucosidase activities in SSF were far higher (53–181 times)compared to SmF. The culture also produced -xylosidase exclu-sively in SSF. Authors concluded that SSF was more likely servedas a natural habitat for the fungus to facilitate the enzyme secre-tion. Barrios-Gonzalez [39] reviewed the physiology of the medium,its molecular basis and applications for SSF and mentioned thatthe higher secondary metabolites production has been related tohigher transcription of the biosynthetic genes. Several studies onenzymes production in SSF have identified SSF-specific genes andprovided deeper insight into their genetic expression and regula-tion. Studies on basic aspects have led to the description of solid