The in vitro antimicrobial activity of different fractions obtained from rhizome of Curcuma longa was
investigated against standard strain and clinical isolates of Staphylococcus aureus. The clinical isolates
were found more sensitive for different fractions, than the standard strain of S. aureus. Scanning electron
microscopic observations revealed that test pathogen treated with C. longa extract showed
morphological deformity, with partial lack of the cytoplasmic membrane, which leads to cell disruption
The ability of rhizome of C. longa extracts to inhibit the growth of test pathogen is an indication of its
broad spectrum antimicrobial potential which may be employed in the management of microbial
infections.