Therefore, 1 has been studied in several media using different
techniques. However, to the best of our knowledge, there is no
study of 1 in water solutions using femtosecond spectroscopy
to observe the early stages of structure conversion and formation.
In this work, we continue our efforts in this direction to provide
a detailed picture of the relaxation dynamics of piroxicam.
Recent reports from this group revealed the presence of very
fast components in the dynamics of piroxicam in organic
solutions, much faster than the previously reported one.
Here, we observed large differences in the femtosecond dynamics
of neutral and ionic forms of 1. The result is explained in
terms of ultrafast proton-transfer, twisting motion, and chargetransfer
processes occurring after UV light excitation of the most
stable structure, which strongly depends on the nature of the
medium.
Therefore, 1 has been studied in several media using differenttechniques. However, to the best of our knowledge, there is nostudy of 1 in water solutions using femtosecond spectroscopyto observe the early stages of structure conversion and formation.In this work, we continue our efforts in this direction to providea detailed picture of the relaxation dynamics of piroxicam.Recent reports from this group revealed the presence of veryfast components in the dynamics of piroxicam in organicsolutions, much faster than the previously reported one.Here, we observed large differences in the femtosecond dynamicsof neutral and ionic forms of 1. The result is explained interms of ultrafast proton-transfer, twisting motion, and chargetransferprocesses occurring after UV light excitation of the moststable structure, which strongly depends on the nature of themedium.
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