For this purpose, three industrially produced cream bases were employed, representing a W/O, an O/W and an amphiphilic cream. Fludrocortisone acetate was added to the vehicles in final concentrations of 0.25, 0.5, 0.75, and 1% (w/w). Skin permeation was investigated by using Franz-type diffusion cells. Additionally, tape stripping experiments were performed to evaluate the penetration of the model drug from the different formulations into porcine ear skin.